Runx2, best known for its role in regulating osteoblast-specific gene expression, also plays an increasingly recognized role in prostate and breast cancer metastasis. Prostate cancer is the most frequently diagnosed nonskin cancer in men and the second leading cause of cancer death in north american males ()the gold standard treatment for localized advanced, recurrent, and metastatic prostate cancer is androgen withdrawal therapy, which blocks the growth-promoting effects of androgens and activates apoptosis (. The potential role of statins in both cancer prevention and treatment is reviewed (70%) , and prostate cancer (56%) among statin users several important clinical questions remain to be addressed about the role of statins in cancer patients first, the tumor types most susceptible to statin therapy have yet to be determined.
To explore the biological role of dkks in prostate cancer, reverse transcription–polymerase chain reaction (rt—pcr) analysis was performed to examine the expression level of dickkopf genes in. B-trcp inhibition reduces prostate cancer cell growth via upregulation of the aryl hydrocarbon receptor udi gluschnaider1, guy hidas1,2, gady cojocaru1, vladimir yutkin1,2, yinon ben-neriah1, eli pikarsky1 1department of pathology and the lautenberg center for immunology, hebrew university hadassah medical school, jerusalem, israel, 2department of urology. Additional studies have demonstrated that tspy is also expressed in prostate cancers and the androgen responsive lncap prostate cancer cell line [9, 26], hepatoma specimens , and melanoma samples and melanoma cell lines the latter studies further substantiate the possible role of tspy in human oncogenesis.
Klf6 (kruppel-like factor 6) is a tumor suppressor protein that is down-regulated or mutated in several types of cancers, including prostate cancer (1–3)klf6 is a zinc finger transcription factor that binds to a gc box and regulates the expression of target genes. Although it is known that the hippo–yap pathway plays an important role in development and cancer in organs such as the liver, skin, intestine, and pancreas , the role for the hippo–yap pathway in prostate cancer biology is emerging. Background prostate cancer (pc) is the most frequently occurring male malignancy worldwide in 2015, more than 220,000 new cases and 27,000 pc-related deaths were reported in. Abstract p57 kip2 has been considered a candidate tumor suppressor gene because of its location in the genome, biochemical activities, and imprinting status however, little is known about the role of p57 kip2 in tumorigenesis and cancer progression here, we show that the expression of p57 kip2 is significantly decreased in human prostate cancer, and the overexpression of p57 kip2 in.
Abstract alternative rna splicing plays an important role in cancer to determine which factors involved in rna processing are essential in prostate cancer, we performed a genome-wide crispr/cas9 knockout screen to identify the genes that are required for prostate cancer growth. To assess the role of grk3 in human cancer, we performed immunohistochemistry (ihc) staining of grk3 protein on a human prostate tumor tissue microarray grk3 was significantly stronger in carcinomas compared with benign prostatic hyperplasias ( p 00005, kruskal–wallis test. To examine the role of bmp-6 in prostate cancer progression, we have developed a bmp-6-regulatable, doxycycline-inducible gene expression system bmp-6 induction by doxycycline addition led to increased levels of bmp-6 rna and protein, associated with nuclear translocation of smads and activation of the downstream target gene id-1.
Squalene synthase expression has been shown to be increased in prostate cancer  , and inhibition of this enzyme has been demonstrated to cause cell death in prostate cancer [75, 76. Prostate stem cell antigen (psca) is a glycosylphosphatidylinositol (gpi) anchored protein expressed not only in prostate but also in pancreas and bladder cancer as shown by immunohistochemistry and mrna analysis. The microarray study intriguingly shows that rassf1c modulates the expression of a number of genes that are involved in cancer development, cell growth and proliferation, cell death, and cell cycle we have validated the expression of some target genes using qrt-pcr.
Consistent with a potential role of tet1 in suppressing cancer metastasis, knocking down tet1 facilitated migration and invasion of both low (lncap) and high (22rv1) invasive prostate cancer cells in an in vitro cell-based assay (figures 2a, 2b and s2. Methods a bladder cell line was engineered to express a doxycycline (dox) regulated shrna against psca to shed light on the psca biological role in tumor growth, microarray analysis was carried out as a function of psca expression. The role of cd164 in metastatic cancer aaron m havens j wang, y-x sun, g heresi, rs taichman prostate cancer as a model for a tumor that frequently metastasizes to bone previously, we have to verify the results from the microarray, we examined several prostate cancer cells for the.